郑板桥
80 percent of flights in Shanghai canceled, over 100 streets see waterlogging as Typhoon Dolphin sets record to travel 6,000km before landfall_我的网站

一 | 这种新的分子癌症治疗方法依赖于一种特定的分子,它可以寻找围绕癌细胞的酸性环境。

A resident wades through floodwaters in a residential compound in Changning district after heavy rain from Typhoon Dolphin drenched Shanghai on August 9, 2026. Photo: IC
As Typhoon Dolphin continues to batter eastern China from Sunday afternoon after making landfall, a new typhoon system, Peilou, the 16th typhoon of the year, formed in the western North Pacific on, creating a rare situation with three typhoons Dolphin, Chan-hom and Peilou active simultaneously.
The National Meteorological Center (NMC) issued its second typhoon red alert of the year on Sunday morning, weather.com.cn reported.
Under the influence of Typhoon Dolphin, Shanghai experienced significant winds and rainfall. As of 5 pm on Sunday, a total of 215,600 people had been relocated from high-risk areas across Shanghai, China Radio International (CRI) reported on Monday.
Shanghai put in place preparatory measures in response to strong winds and heavy rainfall created by Typhoon Dolphin. As of 5 pm on Sunday, waterlogging had been cleared at 155 of the city’s 181 reported waterlogged sites, with response teams from different departments working to address the remaining 26, according to CRI.
Meanwhile, air traffic across East China was seriously influenced by the weather system, with widespread flight cancellations at multiple airports.
More than 80 percent of flights at Shanghai’s Pudong and Hongqiao airports were canceled as of 6 pm on Sunday. Of Shanghai Pudong International Airport’s 889 scheduled arrivals, 760 were canceled, while 729 of 897 departures were grounded. At Shanghai’s Hongqiao International Airport, almost all 431 scheduled arrivals were canceled, while 342 of 431 departing flights were unable to depart.
Typhoon-related flight restrictions also impacted Southwest China’s Sichuan and Chongqing, prompting widespread cancellations of flights to and from the Yangtze River Delta.
A typhoon track and airport impact forecast map from aviation information platform Variflight.com revealed that as many as 44 airports were likley to be affected by Typhoon Dolphin between August 9 to 12.
According to China Meteorological Administration, Typhoon Dolphin has three notable characteristics.
First, it traveled a long distance across the open ocean, showing an unusually long lifespan. The typhoon formed near the International Date Line, and its track length before landfall exceeds 6,000 kilometers. Its period of activity is expected to exceed 15 days – three times that of a typical typhoon. It become the first typhoon on record to form near the International Date Line and made landfall in China with at least tropical-storm strength, Beijing News reported on Sunday.
Second, it underwent explosive intensification and remained at high intensity for an extended period. Within 48 hours of its formation, the typhoon rapidly strengthened into a super typhoon, reaching a peak intensity of 65 meters per second, making it the second-strongest typhoon of the year so far. It maintained super typhoon strength for as long as 5.5 days and has remained at typhoon strength or above for nine days, according to weather.com.cn.
Third, Typhoon Dolphin has an exceptionally large circulation, with a 7-level wind radius of 420 to 450 kilometers and a circulation diameter of about 1,300 kilometers. It is expected to bring more than three days of strong winds to the East China Sea and torrential rain across much of East China, with local rainfall exceeding 600 millimeters at some places. Authorities urge the public to guard against flash floods and geological hazards and avoid coastal, mountainous and river-valley areas, weather.com.cn.
Typhoon Peilou formed at a tropical storm level. At 2 pm, the typhoon’s center was located over the western North Pacific, about 740 kilometers north-northwest of Saipan, Guam, packing winds of up to 65 kilometers per hour near its center, China Central Television (CCTV) reported on Sunday.
The name “Peilou” comes from China’s Macao, referencing a common migratory bird found in the region.
Typhoon Peilou is forecast to move rapidly eastward at a speed of 25 to 30 kilometers per hour, with its intensity gradually strengthening. It is expected to have no impact on China in the coming days, CCTV reported.
According to Zhou Guanbo, the chief weather forecaster at the National Meteorological Center (NMC), July to September is the peak season for typhoon formation, with August seeing the most storms form and make landfall in China.
Zhou said that typhoon activity reaches its peak in August, when the number of storms forming and making landfall in China is the highest of the year. Therefore, having three typhoons or two typhoons active at the same time is not unusual, Beijing News reported on Sunday.
According to Zhou, the Pacific entered an El Nino state in May 2026, with sea surface temperatures in the central and eastern equatorial Pacific continuing to rise. Compared with last year’s La Nina year, typhoons this year are expected to form farther east, allowing them to gain more energy and moisture over the open ocean.
This year, the number of typhoons that have formed and made landfall in July was higher than usual. Five typhoons formed over the western North Pacific and the South China Sea in July, three of which made landfall in China, Beijing News reported, citing the China Meteorological Administration.
In August, six to seven storms are forecast to form – above the long-term average of 5.6 – with two to three expected to make landfall in or significantly affect China, near the average of 2.3.
In August, one to two strong typhoons are expected to move northward into northern and northeastern China. Experts noted that even as the main body of these northward-moving typhoons weaken, their outer circulation and interaction with cold and warm air could trigger widespread extreme rainfall, which need heightened precautions, according to Beijing News.
Global Times
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二 | 但是,为了使细胞有足够的酸性,它们不能是“冷”的肿瘤,这种肿瘤几乎没有免疫活性。这就是被称为STING激动剂的药物发挥作用的地方。这些药物使肿瘤“燃烧”起来,允许免疫系统对其作出反应。然而,找到"冷"癌细胞可能很困难。这就是新的分子癌症疗法发挥作用的地方。研究人员本月在《肿瘤学前沿》(Frontiers of Oncology)杂志上发表了一项关于该分子的研究。

三 | 根据该研究,该分子被称为pH值低的插入肽(pHLIP),它被吸引到酸性环境。

四 | 通过使用该分子引导药物到肿瘤和癌细胞,他们能够将它们踢出"寒冷"的肿瘤范围,推动免疫系统进行反击。然后,他们可以使用免疫检查点抑制剂来有效地移除使免疫系统不至于用力过猛的自然刹车。

五 | 这种分子癌症治疗方法让免疫系统更长时间地对抗癌症。这是一个双重的系统,基本上允许研究人员准确地引导药物到它们需要的地方。近年来,我们已经看到越来越多像这种新的分子癌症治疗方法这样的靶向选择出现了。

六 | 一种针对癌细胞的病毒也一直在进行,我们甚至看到研究人员在测试一种能杀死皮肤癌的凝胶。

七 | 在测试分子癌症治疗方法时,研究人员将pHLIP与STING激动剂耦合在一起,然后对20只患有结肠直肠肿瘤的小鼠进行治疗。他们发现,在一次注射后,18只小鼠的肿瘤在几天内完全消失。在另一组有较大肿瘤的小鼠中,他们看到接受治疗的10只小鼠中有7只肿瘤消失了。
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Published on:06:17:40